Elab Fluor® 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] - E-AB-F1132L

Elab Fluor® 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

Sizes: 100 Tests, 100 Tests×2

Catalogue Numbers: E-AB-F1132L-100, E-AB-F1132L-100×2

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD274/PD-L1

Target Synonym: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1,

Conjugation: Elab Fluor® 488

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Isotype: Rat IgG2b, κ

Clone No.: 10F.9G2

UNIProt ID: Q9EP73

Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Concentration: 5 μL/Test

Control Catalogue Number: E-AB-F09842L

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Gene ID: 60533

Storage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.

Shipping: Ice bag

Research Use Only