Product Description

ELNE Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32147-50, RA32147-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: elastase, neutrophil expressed (ELANE) Homo sapiens Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016

Reactivity: Human, Mouse, Bovine

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 29

Protein Molecular Weight (kDa): 29

Storage: -20°C/1 year

Human Gene ID: 1991

Human SwissProt Number: P08246

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only