Product Description

ENSA Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10880-50, MB10880-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O43768

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase . Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ENSA in rat Brain, C6, 3T3, HelaLysates using ENSA antibody.

Bioworld Molecular Weight: Calculated MW: 13 kDa; Observed MW: 13 kDa

Specificity: IgG

Alternative Name: ARPP-19e

Immunogen: A synthetic peptide of human ENSA

Conjugate: Unconjugated

Modification: Unmodified