Product Description

EphB1/2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1743-50, BS1743-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regμlates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repμlsive interaction with EFNB2. In the adμlt nervous system together with EFNB3, regμlates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regμlate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regμlate cell migration and adhesion respectively.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, IHC, ELISA

Alternate Names: Eph receptor B1+Eph receptor B2, EPH B1, EPH B2, Eph tyrosine kinase 2, Eph tyrosine kinase 3, EPHB1, EPHB2, Ephrin receptor EphB1, Ephrin receptor EphB2, Ephrin type B receptor 1, Ephrin type B receptor 2, EPHT 2, EPHT 3, ERK, Hek 5, Hek 6, Tyrosine protein kinase receptor EPH2, Tyrosine protein kinase receptor EPH3, EPHB1_HUMAN

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human EphB1+EphB2: 901-984/984

Dilution: WB: 1:500~1:2000
IHC: 1:100~1:500
IF: 1:100~1:500
ELISA: 1:5000~1:10000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: EphB1/2 polyclonal antibody detects endogenous levels of EphB1/2 protein.

Molecular Weight: ~ 125 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P54762

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only