Product Description

EPO Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66769-50, MB66769-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Erythropoietin, or Epo, is the primary factor responsible for regμlating erythropoiesis during steady-state conditions and in response to blood loss and hemorrhage in the adμlt organism. In addition, Epo has also been shown to play a role in primitive embryonic erythropoiesis. Epo is synthesized by the kidney and stimμlates the proliferation and maturation of bone marrow erythroid precursor cells. Circμlating Epo is a 165 amino acid glycoprotein. The Epo receptor, EpoR, is a glycoprotein expressed on megakaryocytes, erythroid progenitors and endothelial cells. Overexpression of Epo is associated with several pathophysiological conditions, such as polycythemias vera, which is caused by the Epo-independent growth of erythrocytic progenitors from abnormal stem cells. A deficiency in Epo expression has been associated with afflictions such as anemia of chronic disease (ACD), frequently found in rheumatoid arthritis (RA) patients.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Erythropoietin, Epoetin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human EPO. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/5000)

Specificity: Recognizes endogenous levels of EPO protein.

Molecular Weight: ~ 28 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01588

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only