EpoR rabbit pAb - ES5138

EpoR rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5138-50, ES5138-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Alternate Name: EPOR; Erythropoietin receptor; EPO-R

Source: Rabbit

Applications: WB; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human Epo-R. AA range:341-390

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 65kD

Human Gene ID: 2057

Human SWISS Prot NO: P19235

Subcellular Location: Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted. Secreted and located to the cell surface.

Research Use Only