Product Description

EPX Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60713-50, BS60713-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Eosinophil peroxidase (EPX) is an antimycobacterial protein that localizes to cytoplasmic granμles of eosinophils and recruits bromide to generate a halogenating oxidant. EPX-dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies, cancer, and parasitic/helminthic infections. Human EPX gene product can form a tetramer of two light chains and two heavy chains. EPX is a major enzyme present in eosinophils and upon degranμlation, becomes released into the airways of asthmatics. As a resμlt of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK-dependent manner. Other peroxidase family members include myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Eosinophil peroxidase, EPO, EPX, EPER, EPO, EPP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human EPX

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: EPX polyclonal antibody detects endogenous levels of EPX protein.

Molecular Weight: ~ 81 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P11678

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only