Product Description

ErbB 3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12018-50, MB12018-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P21860

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ErbB 3 in A549, MCF-7Lysates using ErbB 3 antibody.

Bioworld Molecular Weight: Calculated MW: 148 kDa; Observed MW: 185 kDa

Specificity: IgG

Alternative Name: ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

Immunogen: A synthetic peptide of human ErbB 3

Conjugate: Unconjugated

Modification: Unmodified