Erbin (phospho Tyr1104) rabbit pAb - ES1307

Erbin (phospho Tyr1104) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1307-50, ES1307-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Alternate Name: ERBB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2; Densin-180-like protein; Erbb2-interacting protein; Erbin

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Erbin (phospho Tyr1104)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 172kD

Human Gene ID: 55914

Human SWISS Prot NO: Q96RT1

Subcellular Location: Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Research Use Only