ERCC1 Monoclonal Antibody (1B10) - RA11170

ERCC1 Monoclonal Antibody (1B10) Size: 50μL, 100μL Catalogue Numbers: RA11170-50, RA11170-100 Citations, Manuals and MSDS Available upon request. Background: ERCC excision repair 1, endonuclease non-catalytic subunit (ERCC1) Homo sapiens The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol. Storage Instructions: -20°C/1 year Applications: WB; IHC-p; IF (paraffin section) ; Species Cross-Reactivity: Human GeneID (Human): 2067 Protein MW (KDa): 36 SWISS: P07992 Source: Mouse Research Use Only