ERCC1 Monoclonal Antibody - BT-MCA3306

ERCC1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3306-50, BT-MCA3306-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: ERCC1

Applications: WB, IHC, ICC, FCM

Clonality: Monoclonal

Clone ID: 5A2C3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ERCC1

Immunogen: Purified recombinant fragment of human ERCC1 (AA: 1-297) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 32.5kDa

UniProt Accession: P07992

Synonyms: UV20, COFS4, RAD10

GeneID: 2067

Research Use Only