Product Description

ERCC1 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4570-25, MB4570-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene resμlt in cerebroocμlofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Mμltiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecμle, epsilon associated protein gene on the opposite strand. [provided by RefSeq]

Category: Primary Antibody

Reactivity: Human, Rat, Monkey, Mouse

Host: Mouse

Applications: 10k-ChIP, IF, IHC, WB

Alternate Names: COFS4, RAD10, UV20

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll length human recombinant protein of human ERCC1 (NP_973730) produced in HEK293T cell.

Dilution: WB 1:500~1000, IHC 1:150, IF 1:100, FLOW 1:100

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: 32.4 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P07992

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only