Product Description

ERO1LB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65778-50, BS65778-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticμlum to produce disμlfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disμlfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecμlar oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig

Host: Rabbit

Applications: WB

Alternate Names: Endoplasmic oxidoreductin-1-like protein B, ERO1-L-beta, ERO1B_HUMAN, ERO1-like protein beta, Oxidoreductin-1-L-beta.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human ERO1LB:1-100/467

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: ERO1LB Polyclonal Antibody detects endogenous levels of ERO1LB protein.

Molecular Weight: 50 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q86YB8

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only