ESRRA Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90481-50, BS90481-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P11474(Human) O08580(Mouse) Q5QJV7(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IP, , FC
All Applications: WB:1:1,000-1:2,000
FC:1:50-1:100
Background: Estrogen related receptor alpha (ERRα) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of α, β and γ). ERRα plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRα has been shown to increase during fasting and cold exposure. ERRα may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRα are unable to maintain their body temperature in the cold. ERRα may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: ESRRA polyclonal antibody detects endogenous levels of ESRRA protein.
Bioworld Molecular Weight: 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Estrogen Related Receptor alpha on MCF-7 cell lysates using anti-Estrogen Related Receptor alpha antibody at 1/1,000 dilution., Flow cytometric analysis of Hela cells with Estrogen Related Receptor alpha antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Alternative Name: ERR-alpha, ESRRA, ERR1, ESRL1, NR3B1, Err 1, ERR a, ERR alpha, ERR-alpha, Err1, ERR1 protein, ERR1, ERRa, ERRalpha, ESRL 1, ESRL1, ESRR A, Esrra, Estrogen receptor like 1, Estrogen receptor related 1, estrogen receptor related receptor alpha, Estrogen receptor-like 1, Estrogen related receptor alpha, Estrogen-related receptor alpha, Estrra, hERR1, NR3B1, Nuclear receptor subfamily 3 group B member 1, Steroid hormone receptor ERR1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified