Estrogen Receptor beta Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB67166-50, MB67166-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regμlating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regμlatory elements in target genes. Evidence suggests that ERα and ERβ may be regμlated by distinct mechanisms even though they share many functional characteristics. Category: Primary Antibody Reactivity: Human Host: Mouse Applications: WB Alternate Names: ESTRB, NR3A2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Estrogen Receptor beta. The exact sequence is proprietary. Dilution: WB (1/500 - 1/2000) Specificity: Recognizes endogenous levels of Estrogen Receptor beta protein. Molecular Weight: ~ 55 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q92731 Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide. Research Use Only