EWS Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA24737-50, RA24737-100
Citations, Manuals and MSDS Available upon request.
Background: EWS RNA binding protein 1 (EWSR1) Homo sapiens This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been id
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Alternative Names: EWSR1; EWS; RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 2130
Protein MW (KDa): 68
SWISS: Q01844
Source: Rabbit
Research Use Only