Exportin-2 Polyclonal Antibody-BS90484

Exportin-2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90484-50, BS90484-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P55060(Human) Q9ERK4(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC, IF, IHC, FC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin α re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin α and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin α is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Exportin-2 polyclonal antibody detects endogenous levels of Exportin-2 protein.

Bioworld Molecular Weight: 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cellular Apoptosis Susceptibility on different lysates using anti-Cellular Apoptosis Susceptibility antibody at 1/500 dilution.
Positive control:
Lane 1: Mouse testis
Lane 2: SiHa
Lane 3: SK-BR-3
Lane 4: PC-3M, ICC staining Cellular Apoptosis Susceptibility in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: Exp2, CSE1L, CAS, XPO2, CAS, Cellular apoptosis susceptibility protein, Chromosome segregation 1 (yeast homolog) like, Chromosome segregation 1 Like, Chromosome segregation 1 like protein, Chromosome segregation 1-like protein, Chromosome segregation gene CSE1, CSE 1, CSE 1 chromosome segregation 1 like, CSE 1 chromosome segregation 1 like protein, CSE 1L, CSE1, CSE1 chromosome segregation 1 like (yeast), CSE1 chromosome segregation 1 like, CSE1 chromosome segregation 1 like protein, CSE1L, Exp 2, Exp2, Exportin 2, Exportin-2, Exportin2, Importin alpha re exporter, Importin-alpha re-exporter, MGC117283, MGC130036, MGC130037, XPO 2, XPO2, XPO2,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified