Product Description

F5 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60797-50, BS60797-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Hemostasis following tissue injury involves the deployment of essential plasma procoagμlants (prothrombin, and factors X, IX, V, and VIII), which are involved in a blood coagμlation cascade that leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Coagμlation factor V (Factor V, FV, proaccelerin, labile factor) is a 2, 196 amino acid, single chain glycoprotein that is cleaved by thrombin to yield an active, Ca2+ dependent dimer. This heterodimer is essential to the blood coagμlation cascade. Together with catalytic Factor Xa and Ca2+ on the surface of platelets or endothelial cells, Factor Va coordinates in a prothrombinase complex, which mediates proteolysis of prothrombin into active thrombin. Due to both the procoagμlant properties of Factor V in coordinating proteolytic activation of thrombin, and anticoagμlant properties as a cofactor to activated protein C (APC), which selectively destroys FVa and FXa, alterations at the Factor V locus can contribute to hemorrhagic diathesis or thrombosis, respectively.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB

Alternate Names: Coagμlation factor V, Activated protein C cofactor, Proaccelerin, labile factor, F5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human F5.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: F5 polyclonal antibody detects endogenous levels of F5 protein.

Molecular Weight: ~ 252 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12259

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only