Product Description

F8 (S2194) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1119-50, BS1119-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Hemostasis following tissue injury involves the deployment of essential plasma procoagμlants (prothrombin, and Factors X, IX, V, and VIII), which are involved in a blood coagμlation cascade that leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Coagμlation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circμlates as an inactive precursor. Factor IX A, Factor X A, Factor XII A, or thrombin mediated proteolytic cleavage of Factor VII at Arg152-Ile153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disμlfide linked to a light chain, containing 2 EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Coagμlation factor VIII, Antihemophilic factor, AHF, Procoagμlant component, F8C, Factor VIII, FactorVIII, Factor8, Factor 8, Factor-VIII, Factor-8

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 2161-2210 of Human F8.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: F8 (S2194) polyclonal antibody detects endogenous levels of Factor VIII protein.

Molecular Weight: ~ 267 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00451

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only