Product Description

FA7 (light chain, Cleaved-Ala61) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA24808-50, RA24808-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa., disease:Defects in F7 are the cause of factor VII deficiency [MIM:227500]. Factor VII deficiency is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level., function:Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium., online information:Factor VII entry, online information:The Singapore human mutation and polymorphism database, pharmaceutical:Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX., polymorphism:Individuals with the Q allele (Gln-413) seems to have a decreased susceptibility to myocardial infarction., PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains., PTM:The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain., similarity:Contains 1 peptidase S1 domain., similarity:Contains 2 EGF-like domains., subunit:Heterodimer of a light chain and a heavy chain linked by a disulfide bond., tissue specificity:Plasma.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Coagulation factor VII (EC 3.4.21.21;Proconvertin;Serum prothrombin conversion accelerator;SPCA;Eptacog alfa) [Cleaved into: Factor VII light chain, Factor VII heavy chain]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 7

Protein Molecular Weight (kDa): 7

Storage: -20°C/1 year

Human Gene ID: 2155

Human SwissProt Number: P08709

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only