FABP4 Monoclonal Antibody-MB66890

FABP4 Monoclonal Antibody

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Catalogue Numbers: MB66890-50, MB66890-100

Sizes: 50µl, 100µl

Swiss-Prot: P15090

Host: Mouse

Reactivity: Human, Mouse

Applications: WB, IHC

Background: Fatty acid binding proteins bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones . They participate in the transport of fatty acids and other lipids to various cellular pathways . The predominant fatty acid binding protein found in adipocytes is FABP4, also called adipocyte fatty acid binding protein or aP2. FABP4 is also expressed in macrophages . FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes . Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE . Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders .

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification and Purity: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of FABP4 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FABP4 expression in 3T3L1 (A) whole cell lysates., Immunohistochemical analysis of FABP4 staining in human lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Bioworld Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Fatty acid-binding protein, adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4

Immunogen: Recombinant fusion protein of human FABP4. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified