Factor H Polyclonal Antibody-BS90490

Factor H Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90490-50, BS90490-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P08603(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200

Background: The Factor H gene family is a multidomain, multifunctional protein family whose individual members are defined by conserved structural elements, which display diverse yet often overlapping functions. These proteins share a common structural motif, the short consensus repeat (SCR), which is structurally conserved among related genes and between phylogenetically divergent species. The human complement Factor H (FH, CFH, HUS, b-1H) gene encodes a 1213 amino acid serum glycoprotein which is arranged into 20 SCRs, each approximately 60 amino acids long, and an 18-residue leader sequence. Factor H controls the function of the alternative complement pathway and acts as a cofactor with Factor I (C3b inactivator). In addition, Factor H has functional activity outside of the complement system, where it can bind to the cellular integrin receptor (CD11b/CD18), interact with cell surface glycosaminoglycans and associate with the surface of certain pathogenic microorganisms. Deficiencies in Factor H is a common characteristic of acute renal disease.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Factor H polyclonal antibody detects endogenous levels of Factor H protein.

Bioworld Molecular Weight: 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Factor H on human lung tissue lysate using anti-Factor H antibody at 1/1,000 dilution., ICC staining Factor H in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CFH, HF, HF1, HF2, adrenomedullin binding protein, age related maculopathy susceptibility 1, AHUS 1, AHUS1, AMBP 1, AMBP1, ARMD 4, ARMD4, ARMS 1, ARMS1, beta 1 H globulin, beta 1H, beta1H, CFAH, CFH, CFHL 3, CFHL3, Complement factor H, complement factor H, isoform b, Factor H, factor H like 1, FH, FHL 1, FHL1, H factor 1 (complement), H factor 1, H factor 2 (complement), HF 1, HF 2, HF, HF1, HF2, HUS, MGC88246,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified