Factor IX / F9 Polyclonal Antibody - E-AB-60352

Factor IX / F9 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-60352-60, E-AB-60352-120, E-AB-60352-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: Factor IX / F9

Target Synonym: F9; F9 p22; FIX; HEMB; P19; PTC; THPH8; F9p22

Research Areas: Cardiovascular, Immunology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P00740

Background: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human Factor IX / F9 (NP_000124.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Calculated MW: 47kDa/51kDa

Observed MW: 50kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only