Product Description

Factor VIII Polyclonal Antibody

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16436-50, BZ16436-100

Swiss-Prot: P00451

Host: Rabbit

Factor VIII Polyclonal Antibody-BZ16436

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse

Applications: WB, IHC-P, ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background: F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Purification and Purity: Affinity Purified

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 267 kDa; Observed MW: 300 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Factor VIII in HuvEcLysates using Factor VIII antibody., Western blot analysis of Factor VIII in HuvEcLysates using Factor VIII antibody.

Alternative Name: F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component

Immunogen: Synthesized peptide derived from the C-terminal region of human Factor VIII. at AA rangle: 2130-2210

Modification: Unmodified

Conjugate: Unconjugated