Factor X LC (R179) Polyclonal Antibody-BS9421

Factor X LC (R179) Polyclonal Antibody

Catalogue Numbers: BS9421-50, BS9421-100

Sizes: 50µl, 100µl

Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Swiss-Prot: P00742

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor X (Stuart Prower factor, FX, F10) is a vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. The mature form of Factor X (Factor X A) is generated by Factor IX A- or Factor VII A-mediated cleavage at the tripeptide sequence, Arg-Lys-Arg, to yield a disulfide linked dimer. Together with the cofactor Factor V A and Ca2+ on the surface of platelets or endothelial cells, Factor X A coordinates as part of the prothrombinase complex, which mediates proteolysis of Prothrombin into active Thrombin. Mutations at the Factor X locus resulting in Factor X deficiencies can contribute to hemorrhagic diathesis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Factor X LC (R179) polyclonal antibody detects endogenous levels of Factor X LC protein.

Extra Notes: Western blot (WB) analysis of Factor X LC (R179) polyclonal antibody at 1:500 dilution
Lane1:The Liver tissue lysate of Rat(40ug)
Lane2:AML-12 whole cell lysate(40ug)
Lane3:L02 whole cell lysate(40ug)
Lane4:HepG2 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Coagulation factor X; Stuart factor; Stuart-Prower factor; Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain; F10

Immunogen: Synthetic peptide, corresponding to amino acids 41-100 of Human Factor X LC.

Conjugate: Unconjugated

Modification: Unmodified