FAIM2 Polyclonal Antibody-BS62375

FAIM2 Polyclonal Antibody

Catalogue Numbers: BS62375-50, BS62375-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9BWQ8

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB:1:500~1:1000

Background: FAIM2 (fas apoptotic inhibitory molecule 2), also known as LFG (protein lifeguard), TMBIM2 (transmembrane BAX inhibitor motif-containing protein 2) and NMP35 (neural membrane protein 35), is a 316 amino acid multipass membrane protein that uniquely protects cells from Fas-induced apoptosis. Though widely expressed, FAIM2 expression is highest in hippocampus. FAIM2 contains seven transmembrane domains and resembles Bax Inhibitor-1, another anti-apoptotic protein. Overexpression of FAIM2 results in decreased caspase activation and reduced incidence of programmed cell death. Though mechanistically related to the Fas signal, FAIM2 does not protect cells from apoptosis that is mediated by TNF-α signaling. FAIM2 specifically regulates apoptosis by binding to the FAS receptor.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FAIM2 polyclonal antibody detects endogenous levels of FAIM2 protein.

Extra Notes: Western blot (WB) analysis of FAIM2 polyclonal antibody at 1:500 dilution
LaneA:BV2 whole cell lysate
LaneB:U-87MG whole cell lysate
LaneC:HEK293T whole cell lysate

Bioworld Molecular Weight: ~ 36 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2; FAIM2; KIAA0950; LFG; LFG2; NMP35; TMBIM2

Immunogen: Synthetic peptide, corresponding to Human FAIM2.

Conjugate: Unconjugated

Modification: Unmodified