Product Description

FAIM3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8127-50, BS8127-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cytotoxic T lymphocyte (CTL)-mediated cytotoxicty constitutes an important component of specific effector mechanisms in immuno- surveillance against virus-infected or -transformed cells. One mechanism for this activity involves the transducing molecμle FAS (APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellμler interactions of FAS with its ligand or effectors, and may be critically involved in CTL-mediated cytoxicity. Toso was identified as a cell surface protein that is expressed in lymphoid cells. Toso blocks apoptosis mediated by members of the TNF family, including FAS, and has been shown to inhibit TCR induced T cell self-killing.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IF

Alternate Names: Fas apoptotic inhibitory molecμle 3, Regμlator of Fas-induced apoptosis Toso, FAIM3, TOSO

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human FAIM3.

Dilution: WB 1:500 - 1:2000 IF 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: FAIM3 polyclonal antibody detects endogenous levels of FAIM3 protein.

Molecular Weight: ~ 43 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60667

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only