Product Description

FAP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90492-50, BS90492-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q12884(Human) P97321(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC FC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
FC:1:50-1:100

Background: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FAP polyclonal antibody detects endogenous levels of FAP protein.

Bioworld Molecular Weight: 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FAP on Siha cell lysate using anti-FAP antibody at 1/1,000 dilution., ICC staining FAP in NIH-3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: FAPalpha, SIMP, Seprase, APCE, Adenomatous Polyposis Coli, Adenomatous polyposis coli protein, Apc, APC, CC1, Deleted in polyposis 2.5, DP2, DP2.5, DP3, FAP, FPC, GS, Protein APC,

Immunogen: Peptide

Conjugate: Unconjugated

Modification: Unmodified