Product Description

Fascin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66194-50, MB66194-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fascin is a monomeric, globμlar protein that plays a central role in regμlating the structure and function of the cortical actin cytoskeleton . Fascin promotes cross-linkage of parallel actin filaments during the formation of cell protrusions (lamellipodia and filopodia), and therefore plays an important role in regμlating cell migration. It has been reported that fascin may also regμlate filopodia formation by a mechanism independent of its actin-bundling functions , though less is known about this mechanism of action. Research studies have shown that increased fascin expression is associated with increased motility and invasiveness of neoplastic cells, including breast, colon, prostate, and esophageal squamous cell carcinomas . Fascin binds to the armadillo-repeat domain of β-catenin in vitro and in vivo, and has been shown to co-localize with β-catenin and cadherins at the leading edge of migratory cells.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC, IF

Alternate Names: FAN1, HSN, SNL, Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Fascin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300), IF (1/100 - 1/500)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Fascin protein.

Molecular Weight: ~ 54 kDa

Pathway: Regμlation of Actin Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16658

Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only