FBLI1 rabbit pAb - ES16512

FBLI1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES16512-50, ES16512-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human FBLI1 AA range: 157-207

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 54751

Human SWISS Prot NO: Q8WUP2

Subcellular Location: Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242).

Research Use Only