FBN1 rabbit pAb - ES5222

FBN1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5222-50, ES5222-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016],

Alternate Name: FBN1; FBN; Fibrillin-1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Fibrillin-1. AA range:2811-2860

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 2200

Human SWISS Prot NO: P35555

Subcellular Location: Secreted. Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166).; [Fibrillin-1]: Secreted, extracellular space, extracellular matrix.; [Asprosin]: Secreted. Secreted by white adipose tissue and circulates in the plasma.

Research Use Only