Product Description

Fbx32 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65604-50, BS65604-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q969P5

Host: Rabbit

Reactivity: Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )

Applications: FCM

All Applications: Flow-Cyt=2ug/Test

Background: Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Fbx32 Polyclonal Antibody detects endogenous levels of Fbx32 protein.

Bioworld Molecular Weight: 42kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.

Immunogen: KLH conjugated synthetic peptide derived from human MAFbx:31-130/355

Conjugate: Unconjugated

Modification: Unmodified