FBXL18 Polyclonal Antibody-BS90498

FBXL18 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90498-50, BS90498-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96ME1(Human)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC FC

All Applications: WB:1:500
IHC:1:50-1:200
FC:1:50-1:100

Background: FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.

Purification and Purity: Peptide affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: FBXL18 polyclonal antibody detects endogenous levels of FBXL18 protein.

Bioworld Molecular Weight: 88/40 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FBXL18 on PC-3M cell lysate using anti-FBXL18 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-FBXL18 antibody. Counter stained with hematoxylin.

Alternative Name: FBXL18, FBL18, F box and leucine rich repeat protein 18, F box/LRR repeat protein 18, FBL18, FBXL 18, FLJ10776, FLJ11467, FLJ26934, FLJ38075, FLJ41541,

Immunogen: Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.

Conjugate: Unconjugated

Modification: Unmodified