Product Description

FEN1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66591-50, MB66591-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with mμltiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double-stranded DNA breaks in long patch base excision repair. The mμlti-functional activities of FEN-1 are regμlated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellμlar re-localization in response to cell cycle or DNA damage.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey, Hamster

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: RAD2, Flap endonuclease 1, FEN-1, DNase IV, Flap structure-specific endonuclease 1, Maturation factor 1, MF1, hFEN-1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human FEN-1 protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of FEN1 protein.

Molecular Weight: ~ 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P39748

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only