FGA Monoclonal Antibody-MB66776

FGA Monoclonal Antibody

Catalogue Numbers: MB66776-50, MB66776-100

Sizes: 50µl, 100µl

Product: Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P02671

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: α, β and γ. Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities and are mitogens for several cell types.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of FGA protein.

Extra Notes: Western blot analysis of FGA expression in human liver (A), mouse liver (B), mouse bladder (C) whole cell lysates.

Bioworld Molecular Weight: ~ 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Fibrinogen alpha chain

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human FGA. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified