FGD4 rabbit pAb - ES16482

FGD4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES16482-50, ES16482-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Alternate Name: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)

Source: Rabbit

Applications: WB

Dilution: WB 1:500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human FGD4 AA range: 291-341

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 85kD

Human Gene ID: 121512

Human SWISS Prot NO: Q96M96

Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, filopodium. Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity).

Research Use Only