Product Description

FGD4 Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10033-20, BT-AP10033-50, BT-AP10033-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain| which together with its Dbl homology domain and one of its pleckstrin homology domains| can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain| and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum| an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H)| a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Signal transduction

Target Protein: FGD4

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: FGD4

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96M96; Mouse: Q91ZT5; Rat: O88387

Synonyms: FGD4; FYVE; RhoGEF and PH domain-containing protein 4; Actin filament-binding protein frabin; FGD1-related F-actin-binding protein; Zinc finger FYVE domain-containing protein 6)

GeneID: Human: 121512; Mouse: 224014; Rat: 246174

Research Use Only