FGD4 Rabbit Polyclonal Antibody - RA32315

FGD4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32315-50, RA32315-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.315% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 121512

Protein MW (KDa): 85

SWISS: Q96M96

Source: Rabbit

Research Use Only