Product Description

FGD5 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS76180-50, BS76180-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: FGD5 (or ZFYVE23) is an endothelial specific gene, plays a crucial role in vascμlar pruning. Deficient expression of FGD5 markedly inhibits neovascμlarization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. FGD5-deficient endothelial cells fail to migrate. Moreover, the cells are susceptible to proapoptotic stimμli associated with VEGF-stimμlated activation of Akt. FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of CDC42.

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB

Alternate Names: FGD5, ZFYVE23, FYVE

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human FGD5(NP_689749.3).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 178kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6ZNL6

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only