Product Description

FGFR1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90506-50, BS90506-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P11362(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF

All Applications: WB:1:1,000
ICC:1:50-1:100

Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor (FGFR-1), the Bek receptor (FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Flg maps to chromosome 8p12 and is alternatively spliced to produce several isoforms. Mutations in Flg are associated with Pfeiffer syndrome (a skeletal disorder characterized by craniosynostosis with deviation and enlargement of the thumbs and great toes), brachymesophalangy with phalangeal ankylosis and a varying degree of soft tissue syndactyly. The Flg gene is also involved in chromosomal translocations with ZNF198, CEP110 and FOP, which may lead to stem cell leukemia lymphoma (SCLL).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FGFR1 polyclonal antibody detects endogenous levels of FGFR1 protein.

Bioworld Molecular Weight: 100,140 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FGFR1 on 293 cells lysates using anti-FGFR1 antibody at 1/1,000 dilution., ICC staining FGFR1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: FGFR-1, BFGFR, bFGF-R-1, FLT-2, FGFR1, Basic fibroblast growth factor receptor 1, bFGF-R-1, BFGFR, CD331, CEK, FGFBR, FGFR 1, FGFR-1, FGFR1, FGFR1/PLAG1 fusion, FGFR1, fibroblast growth factor receptor 1, FLG, FLT-2, FLT2, Fms-like gene, Fms-like tyrosine kinase 2, fms-related tyrosine kinase 2, HBGFR, heparin-binding growth factor receptor, HH2, HRTFDS, hydroxyaryl-protein kinase, KAL2, N-SAM, OGD, Proto-oncogene c-Fgr,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified