Product Description

FGFR1 (R148) Polyclonal Antibody

Catalogue Numbers: BS3620-50, BS3620-100

Sizes: 50µl, 100µl

Alternative Name: Fibroblast growth factor receptor 1; FGFR-1; 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; FGFR1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P11362

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB: 1:500~1:1000
IF: 1:50~1:200

Background: FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FGFR1 (R148) polyclonal antibody detects endogenous levels of FGFR1 protein.

Bioworld Molecular Weight: ~ 120,145 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of FGFR1 (R148) polyclonal antibody at 1:1000 dilution
Lane 1: MCF-7 whole cell lysate(48ug) Lane 2: The Kidney tissue lysate of Rat(47ug) Lane 3: The Kidney tissue lysate of Mouse(37ug)

Immunogen: Synthetic peptide, corresponding to amino acids 118-160 of Human FGFR1.

Conjugate: Unconjugated

Modification: Unmodified