FGFR3 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90509-50, BS90509-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P22607(Human) Q61851(Mouse) Unigene:23671(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC, FC
All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia (7-10). Mutations in FGFR-3 are also a cause of some bladder and cervical cancers (11).
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: FGFR3 polyclonal antibody detects endogenous levels of FGFR3 protein.
Bioworld Molecular Weight: 98 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of FGFR3 on different cells lysates using anti-FGFR3 antibody at 1/500 dilution.
Positive control: Line 1: 293 Line 2: HepG2, ICC staining FGFR3 in MCF-7 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: FGFR-3, FGFR3, ACH, CD 333, CD333, CD333 antigen, CEK 2, CEK2, FGFR 3, FGFR-3, FGFR3, FGFR3, Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism), Fibroblast growth factor receptor 3, Heparin binding growth factor receptor, HSFGFR3EX, Hydroxyaryl protein kinase, JTK 4, JTK4, MFR 3, SAM 3, Tyrosine kinase JTK 4, Tyrosine kinase JTK4, Z FGFR 3,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified