FH Fumarase Monoclonal Antibody (2B11) - BT-MCA0536

FH Fumarase Monoclonal Antibody (2B11)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0536-20, BT-MCA0536-50, BT-MCA0536-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Research Areas: Signal transduction; Cancer; Metabolism

Target Protein: FH

Applications: WB, IF, ICC

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Fumarate hydratase, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P07954; Mouse: P97807; Rat: P14408

Synonyms: Fumarate hydratase; mitochondrial

GeneID: Human: 2271; Mouse: 14194

Research Use Only