FH rabbit pAb - ES20754

FH rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20754-50, ES20754-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008],

Alternate Name: Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)

Source: Rabbit

Applications: WB

Dilution: WB: 1:1000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of Fumarate hydratase, mitochondrial

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 50kD

Human Gene ID: 2271

Human SWISS Prot NO: P07954

Subcellular Location: [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm, cytosol. Nucleus. Chromosome. Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC.

Research Use Only