FHIT Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1196-20, A1196-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a P1-P3-bis (5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 17kDa
Observed Molecular Weight: 17kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2272
SWISS: P49789
Alternate Names: FRA3B; AP3Aase; FHIT
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Cancer, Tumor suppressors.
NCBI Alias: FHIT
Research Use Only