FHR5 Rabbit Polyclonal Antibody - BT-AP02686

FHR5 Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02686-20, BT-AP02686-50, BT-AP02686-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties| a region within repeats 5-7 having heparin binding and C reactive protein binding properties| and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3| binds C3b in a dose-dependent manner| and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated| but not causally linked| with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Research Areas: Immunology

Target Protein: CFHR5

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: FHR5

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9BXR6

Synonyms: FHR5; Complement factor H-related protein 5; FHR-5)

GeneID: Human: 81494

Research Use Only