FHR5 Rabbit Polyclonal Antibody - RA32328

FHR5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32328-50, RA32328-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS) . [provided by RefSeq, Jan 2010],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Complement factor H-related protein 5 (FHR-5)

Applications: WB

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 81494

Protein MW (KDa): 60

SWISS: Q9BXR6

Source: Rabbit

Research Use Only