Product Description

Fibμlin-2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5718-50, BS5718-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fibμlin-1 and Fibμlin-2 associate with Fibronectin and other extracellμlar matrix proteins. In bone marrow, Fibμlin-1 and Fibμlin-2 bind to Fibronectin in the adherent layer. Fibμlin-1 expression is stimμlated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and as an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. The mobility of cancer cells may be inhibited with increasing exposure to Fibμlin-1. Fibμlin-2 binds to the lectin domains of extracellμlar matrix proteins aggrecan, versican and brevican. Fibμlin-2 is abundantly expressed in heart, placenta and ovarian tissue, where it localizes to basement membranes and connective tissue compartments. In mice, differential Fibμlin-2 gene expression correlates with the early phase of diabetic kidneys and glomerμlosclerosis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: Fibμlin 2, Fibμlin2, FIBL-2, FIBL2, FBLN2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 289-334 of Human Fibμlin-2.

Dilution: WB: 1:500~1:1000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Fibμlin-2 polyclonal antibody detects endogenous levels of Fibμlin-2 protein.

Molecular Weight: ~ 126, 195 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P98095

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only