Fibrinogen Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90512-50, BS90512-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P02671/P02675/P02679(Human)
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, ICC FC
All Applications: WB:1:500
ICC:1:100-1:500
FC:1:50-1:100
Background: The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: a, b and g. Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Fibrinogen polyclonal antibody detects endogenous levels of Fibrinogen protein.
Bioworld Molecular Weight: 70/55 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Fibrinogen on mouse bone marrow and human kidney tissue lysates using anti-Fibrinogen antibody at 1/500 dilution., ICC staining Fibrinogen in NIH-3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: FGA, FGB, FGG, FGA, Fib2, FIBA, Fibrinogen A alpha polypeptide, Fibrinogen alpha chain, Fibrinogen B alpha polypeptide, Fibrinogen beta chain, Fibrinogen G alpha polypeptide, Fibrinogen gamma chain, fibrinogen, B beta polypeptide, fibrinogen, G gamma polypeptide, fibrinogen, gamma polypeptide, Fibrinogenalpha -polypeptide chain, Fibrinogenbeta -polypeptide chain, Fibrinogengamma-polypeptide chain,
Immunogen: Native protein.
Conjugate: Unconjugated
Modification: Unmodified