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Fibulin 5 Polyclonal Antibody-BS90515

Fibulin 5 Polyclonal Antibody-BS90515

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Fibulin 5 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90515-50, BS90515-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UBX5(Human) Q9WVH9(Mouse) Q9WVH8(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IHC FC

All Applications: WB:1:1,000-1:2,000
ICC:1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Fibulin proteins contribute to normal development of elastic fiber systems in various types of organs that require elasticity, such as vasculature, lung and skin. Fibulin-5 (EVEC, UP50, DANCE) is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion. Fibulin-5 is also a calcium-dependent elastin-binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the skin, lung, and vasculature. The Arg-Gly-Asp (RGD) motif in Fibulin-5 interacts with cell surface integrins avb3, avb5 and a9b1, serves as an anchorage for elastic fibers to cells, and promotes organization of elastic fibers. The human Fibulin-5 gene maps to chromosome 14q32.12 and encodes a 488 amino acid protein.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Fibulin 5 polyclonal antibody detects endogenous levels of Fibulin 5 protein.

Bioworld Molecular Weight: 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Fibulin 5 on human skin tissue lysate using anti-Fibulin 5 antibody at 1/1,000 dilution., ICC staining Fibulin 5 in JAR cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: FIBL-5, Dance, UP50, FBLN5, DANCE, ADCL2, ARCL1A, ARMD3, Dance, Developmental arteries and neural crest EGF like protein, Developmental arteries and neural crest EGF-like protein, EVEC, Fbln5, FBLN5, FIBL 5, FIBL-5, Fibulin-5, FLJ90059, UP50, Urine p50 protein,

Immunogen: Recombinant protein within human Fibulin 5 210-360 aa.

Conjugate: Unconjugated

Modification: Unmodified